Leicester eliminated Brighton in the last round while Man United beat West Ham to face themselves.
These different sides are isolated by a point in the Premier League and are both anxious to get a top four slot this season.
They played a 2-2 draw chiller on Boxing Day and will today go head to head for a spot in the cup FA CUP semi-finals.
The draw for the last four will at that point be made in the half-season of this game.
Following his first question and answer session (press conference) since joining Bayer Leverkusen, Demarai Gray discloses his choice to leave Leicester.
Leicester v Man United: Team news:
Leicester v Man United: Match realities
Manchester United have won every one of the past two FA Cup conflicts with Leicester City, a 2-1 success in the fifth round in 1976 and a 3-1 triumph in the 1963 last of the opposition – lifting the prize for the third time.
Leicester have won only one of their last 25 gatherings with Manchester United on the whole rivalries (D5 L19), and none of the last 13 (D4 L9) since a 5-3 success at home in September 2014 in the Premier League.
Manchester United are hoping to arrive at the FA Cup semi-finals for a record 31st time, with the Red Devils right now level with Arsenal on appearances in the last four of the opposition.
Leicester, who have lost every one of their last five quarter-last ties in the FA Cup, last arrived at the semi-last of the opposition back in 1982, when they lost 0-2 to inevitable champs Tottenham Hotspur at Villa Park.
Leicester have however won 6 of their last 8 FA Cup home matches (L2), however both of their losses across this run have come at the quarter-last stage against Chelsea, in 2017-18 and 2019-20.
Manchester United have been on form as they have won 12 of their last 15 away matches of FA Cup (D1 L2), with their two losses during this run coming at the quarter-last stage, versus Chelsea in 2016-17 and Wolves in 2018-19.
Barring own objectives, just Bristol Rovers and Spurs (9) have had more unique goalscorers in this present season’s FA Cup than Leicester City, with every one of their eight objectives coming from an alternate player (Justin, Albrighton, Pérez, Barnes, Ünder, Tielemans, Maddison and Iheanacho).
Just against Brighton (5) and Southampton (6) has Manchester United supervisor Ole Gunnar Solskjær assumed responsibility for additional matches at English clubs without losing than he has versus Leicester (P4 W3 D1 L0).